World Congress and Exhibition on
Pharmaceutics and Drug Delivery

This track will include the usage of Pharmacokinetics and Pharmacodynamics in Drugs. Pharmacology is basically  the study of drugs. Pharmacodynamics is the effect that drugs have on the body. Pharmacokinetics is the effect the body has on the drugs. Pharmacokinetics includes absorption, distribution, metabolism and excretion of drugs.

Few major topics of this session will be: Pharmacokinetic Parameters, Pharmacodynamic Parameters, Absorption of Drugs, Distribution of Drugs, Biotransformation/Metabolism, Excretion of Drugs, Pharmacodynamics

In this session we will talk about the main objective in drug design and drug targeting. Drug design is to foresee whether a given particle will bind to a target and if so how unequivocally. Molecular mechanics or molecular dynamics are regularly used to predict the conformation of the little particle and to model conformational changes in the biological targets that may happen when the little molecules ties to it. The remedial reaction of a drug relies on the cooperation of drug molecules with cell on cell membrane related biological events at receptor sites in concentration dependent manner.

Few major tracks of this session will be: Drug Targeting strategies, Factors influencing Drug Targeting, Advances in Drug Targeting components, Recent Approaches to Drug Targeting, Rational Drug Design, Computer Aided Drug Design

In this session we will talk about the route of administration in pharmacology and toxicology which is basically the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied.

Few major tracks of this session will be: Oral Drug Delivery, Buccal Drug Delivery, Nasal Drug Delivery,  Ophthalmic Drug Delivery, Topical Drug Delivery, Pulmonary Drug Delivery, Parenteral Drug Delivery, Rectal Drug Delivery, Vaginal Drug Delivery, Geriatric Drug Delivery, Pediatric Drug Delivery

This track will includes  Nanoparticle technology which recently showed to hold a great promise for drug delivery applications in nanomedicine due to its beneficial properties, such as better encapsulation, bioavailability, control release, and lower toxic effect. Despite the great progress in nanomedicine, there remain many limitations for clinical applications on nanocarriers. Synthesizing nanoparticles for pharmaceutical purposes such as drug preparation can be done in two methods. Bottom up process such as pyrolysis, inert gas condensation, solvothermal reaction, sol-gel fabrication and structured media in which hydrophobic compound such as liposomes are used as bases to mount the drug. Top down process such as attrition / milling in which the drug is chiseled down to form a nanoparticle.To overcome these limitations, advanced nanoparticles for drug delivery have been developed to enable the spatially and temporally controlled release of drugs in response to specific stimuli at disease sites. Furthermore, the controlled self-assembly of organic and inorganic materials may enable their use in theranostic applications. This review presents an overview of a recent advanced nanoparticulate system that can be used as a potential drug delivery carrier and focuses on the potential applications of nanoparticles in various biomedical fields for human health care. A novel process for synthesis of polymeric nanoparticles for use in drug delivery applicationsusing the electrospraying technique. The technologyis standardized for synthesis of natural polymer based nanoparticles such as chitosan-gelatin based nanoparticles.

Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology such as biological machines. Using nanoparticle contrast agents, images such as ultrasound and MRI have a favorable distribution and improved contrast. This might be accomplished by self assembled biocompatible nanodevices that will detect, evaluate, treat and report to the clinical doctor automatically. Nanotechnology ("nanotech") is manipulation of matter on an atomic, molecular, and supramolecular scale. The earliest, widespread description of nanotechnology referred to the particular technological goal of precisely manipulating atoms and molecules for fabrication of macro scale products, also now referred to as molecular nanotechnology. A more generalized description of nanotechnology was subsequently established by the National Nanotechnology Initiative, which defines nanotechnology as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers.

Nano pharmaceuticals offer the ability to detect diseases at much earlier stages and the diagnostic applications could build upon conventional procedures using nanoparticles. Nano pharmaceuticals represent an emerging field where the sizes of the drug particle or a therapeutic delivery system work at the Nano scale. In the pharmaceutical industry, a long standing issue is the difficulty of delivering the appropriate dose of a particular active agent to specific disease site. Nano pharmaceuticals have enormous potential in addressing this failure of traditional therapeutics which offers site-specific targeting of active agents. Such precision targeting via Nano pharmaceuticals reduces toxic systemic side effects, resulting in better patient compliance. In today world economy, a pharmaceutical industry faces enormous pressure to deliver high-quality products to patients while maintaining profitability. Therefore pharmaceutical companies are applying nanotechnology to enhance or supplement drug target discovery and drug delivery. Nano pharmaceutical reduces the cost of drug discovery, design & development and enhances the drug delivery process.

With Smart Drug Delivery Technology the unprecedented progresses of biomedical nanotechnology during the past few decades, conventional drug delivery systems (DDSs) have been involved into smart DDSs with stimuli-responsive characteristics. To enhance their therapeutic effects and reduce the related side effects, active drug molecules should selectively accumulate in the disease area for a prolonged period with high controllability. Drug delivery refers to the approaches, formulations, technologies, and systems for transporting therapeutics in the body as needed to safely and efficiently achieve their desired therapeutic effects. Conventional drug delivery systems  (DDSs) are often accompanied by systemic side effects that mainly attributable to their nonspecific bio-distribution and uncontrollable drug release characteristics. To overcome these limitations, advanced controlled DDSs have been developed to achieve the release of payloads at the target sites in a spatial controlled manner. In comparison to the conventional DDSs, the smart controlled DDSs can effectively reduce the dosage frequency, while maintaining the drug concentration in targeted organs/tissues for a longer period of time. In this sense, the controlled DDSs provide broad insights and fascinating properties for decreasing drug concentration fluctuation, reducing drug toxicities and improving therapeutic efficacy.

This track will includes  Nanoparticle technology which recently showed to hold a great promise for drug delivery applications in nanomedicine due to its beneficial properties, such as better encapsulation, bioavailability, control release, and lower toxic effect. Despite the great progress in nanomedicine, there remain many limitations for clinical applications on nanocarriers. Synthesizing nanoparticles for pharmaceutical purposes such as drug preparation can be done in two methods. Bottom up process such as pyrolysis, inert gas condensation, solvothermal reaction, sol-gel fabrication and structured media in which hydrophobic compound such as liposomes are used as bases to mount the drug. Top down process such as attrition / milling in which the drug is chiseled down to form a nanoparticle.To overcome these limitations, advanced nanoparticles for drug delivery have been developed to enable the spatially and temporally controlled release of drugs in response to specific stimuli at disease sites. Furthermore, the controlled self-assembly of organic and inorganic materials may enable their use in theranostic applications. This review presents an overview of a recent advanced nanoparticulate system that can be used as a potential drug delivery carrier and focuses on the potential applications of nanoparticles in various biomedical fields for human health care. A novel process for synthesis of polymeric nanoparticles for use in drug delivery applicationsusing the electrospraying technique. The technologyis standardized for synthesis of natural polymer based nanoparticles such as chitosan-gelatin based nanoparticles.

Vaccine is a material that induces an immunologically mediated resistance to a disease but not necessarily an infection. Vaccines are generally composed of killed or attenuated organisms or subunits of organisms or DNA encoding antigenic proteins of pathogens. Sub-unit vaccines though exceptionally selective and specific in reacting with antibodies often fail to show such reactions in circumstances such as shifts in epitopic identification center of antibody and are poorly immunogenic. Delivery of antigens from oil-based adjuvants such as Freunds adjuvant lead to a reduction in the number of doses of vaccine to be administered but due to toxicity concerns like inductions of granulomas at the injection site, such adjuvants are not widely used. FDA approved adjuvants for human uses are aluminium hydroxide and aluminium phosphate in the form of alum. Hence, search for safer and potent adjuvants resulted in the formulations of antigen into delivery systems that administer antigen in particulate form rather than solution form.